Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction

Telêmaco Luis da Silva, Antonio Pazin-Filho, Minna M D Romano, Virgínia P L Ferriani, José A Marin-Neto, Benedito C Maciel and André Schmidt

PLOS ONE, 2021, vol. 16, issue 11, 1-12

Abstract: Background: Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well established. Objective: To investigate the prognostic value of DEC in patients with ARF as a predictor of chronic valve dysfunction. Methods: Prospectively enrolled patients with clinical ARF had a DEC performed soon after diagnosis and repeated at 1, 3, 6 and 12 months and thereafter at every 1–2 years. We defined chronic valve dysfunction by ≥ 3 of the following: increased valve thickening, commissure fusion, subvalvular thickening, reduced leaflet mobility, non-trivial mitral and/or aortic regurgitation. We performed univariate analysis and developed multivariate logistic regression models to identify variables that may influence evolution to RHD. p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0259737

DOI: 10.1371/journal.pone.0259737

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