Obstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study

Zhu Wei Lim, I-Duo Wang, Panchalli Wang, Chi-Hsiang Chung, Song-Shan Huang, Chien-Chu Huang, Pei-Yi Tsai, Gwo-Jang Wu, Kuo-Hsiang Wu and Wu-Chien Chien

PLOS ONE, 2021, vol. 16, issue 12, 1-12

Abstract: Objectives: To determine the risk of having OSA in a cohort of female subjects who are infertile and the odds of being infertile in women with OSA. Patients and methods: A nationwide, case-control study of female patients 20 years or older diagnosed with female infertility living in Taiwan, from January 1, 2000, through December 31, 2013 (N = 4,078). We identified women who were infertile and created a 2:1 matched control group with women who were not infertile. We used multivariable logistic regression analysis to further estimate the effects of OSA on female infertility. Results: In this 14- year retrospective study, we included 4,078 patients having an initial diagnosis of female infertility. Of those women with infertility, 1.38% had a history of OSA compared with 0.63% of fertile controls (p = 0.002). The mean ages in the study groups were 32.19 ± 6.20 years, whereas the mean ages in the control groups were 32.24 ± 6.37years. Women with OSA had 2.101- times the risk of female infertility compared to women without OSA (p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0260842

DOI: 10.1371/journal.pone.0260842

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