Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes

Waheed Ul-Rahman Ahmed, Manal I A Patel, Michael Ng, James McVeigh, Krina Zondervan, Akira Wiberg and Dominic Furniss

PLOS ONE, 2022, vol. 17, issue 12, 1-27

Abstract: Abdominal hernias are common and characterised by the abnormal protrusion of a viscus through the wall of the abdominal cavity. The global incidence is 18.5 million annually and there are limited non-surgical treatments. To improve understanding of common hernia aetiopathology, we performed a six-stage genome-wide association study (GWAS) of 62,637 UK Biobank participants with either single or multiple hernia phenotypes including inguinal, femoral, umbilical and hiatus hernia. Additionally, we performed multivariable meta-analysis with metaUSAT, to allow integration of summary data across traits to generate combined effect estimates. On individual hernia analysis, we identified 3404 variants across 38 genome-wide significant (p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0272261

DOI: 10.1371/journal.pone.0272261

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