Obesity in children and adolescents and the risk of ovarian cancer: A systematic review and dose‒response meta-analysis

Nan Ding, Junyi Zhan, Youjin Shi, Tianci Qiao, Panpan Li and Tingting Zhang

PLOS ONE, 2022, vol. 17, issue 12, 1-14

Abstract: Objective: The relationship between obesity in children and adolescents and the risk of ovarian cancer remains controversial. The aim of this meta-analysis was to explore the exact shape of this relationship. Methods: We conducted dose‒response meta-analyses of cohort and case‒control studies, including published studies derived from searches in the PubMed, Embase, Web of Science and Cochrane Library databases until October 2022. Pooled effect size estimates are expressed as relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) and were evaluated by fixed-effect models. A nonlinear dose‒response meta-analysis was performed by using a restricted cubic spline model. Results: After screening 4215 publications, 10 studies were included in the present meta-analysis. Overall analyses revealed statistically significant associations of obesity in children and adolescents with ovarian cancer (adjusted RR = 1.19, 95% CI: 1.11 to 1.28, P

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0278050

DOI: 10.1371/journal.pone.0278050

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