Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study

Kelly Thompson, Naomi Hammond, Michael Bailey, Jai Darvall, Gary Low, Steven McGloughlin, Lucy Modra and David Pilcher

PLOS ONE, 2023, vol. 18, issue 2, 1-14

Abstract: Objective: To determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years. Methods: Retrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-years was examined using Kaplan Meier plots. Secondary outcomes included the duration of ICU and hospital stay. Results: Of 523,576 admissions, there were 63,039 (12·0%) sepsis-related ICU admissions. Of these, there were 50,956 patients (43·4% women) with 3-year survival data. Men were older (mean age 66·5 vs 63·6 years), more commonly received mechanical ventilation (27·4% vs 24·7%) and renal replacement therapy (8·2% vs 6·8%) and had worse survival (Hazard Ratio [HR] 1·11; 95% Confidence Interval [CI] 1·07 to 1·14, P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0281939

DOI: 10.1371/journal.pone.0281939

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