Diagnostic accuracy of the Copenhagen Index in ovarian malignancy: A meta-analysis

Huiling Liu, Shouye Ma, Xiaohong Chen, Huifang Wu, Rongrong Wang, Mengmeng Du and Xiazi Nie

PLOS ONE, 2023, vol. 18, issue 6, 1-11

Abstract: Objective: To assess the diagnostic value of the Copenhagen index for ovarian malignancy. Methods: PubMed, Web of Science, the Cochrane Library, Embase, CBM, CNKI, and WanFang databases were searched throughout June 2021. Statistical analyses were performed using Stata 12, Meta-DiSc, and RevMan 5.3. The pooled sensitivity, specificity, and diagnostic odds ratio were calculated, the summary receiver operating characteristic curve was drawn, and the area under the curve was calculated. Results: Ten articles, including 11 studies with a total of 5266 patients, were included. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.82 [95% CI (0.80–0.83)], 0.88 [95% CI (0.87–0.89)], and 57.31 [95% CI (32.84–100.02)], respectively. The area under the summary receiver operating characteristics curve and the Q index were 0.9545 and 0.8966, respectively. Conclusion: Our systematic review shows that the sensitivity and specificity of the Copenhagen index are high enough for it to be used in a clinical setting to provide accurate ovarian cancer diagnosis without considering menopausal status.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0286650

DOI: 10.1371/journal.pone.0286650

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