The association of manganese levels with red cell distribution width: A population-based study

Guanmian Dai, Huanhuan Sun, Yanli Lan, Jinhong Jiang and Bingmu Fang

PLOS ONE, 2024, vol. 19, issue 8, 1-13

Abstract: Objectives: Experimental and acute exposure studies imply that manganese affects red blood cell production. Nevertheless, the association between environmental exposure and red blood cell distribution width (RDW) has yet to be explored. This research sought to assess the correlation between blood manganese levels and RDW within the general population of the United States. Materials and methods: Employing weighted multiple linear regression models, data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) were utilized to assess the correlation between manganese levels in the blood and RDW. Restricted cubic spline plots and two-piecewise linear regression models were also employed. Result: The analysis included a total of 15882 participants in which we determined an independent positive relationship between blood manganese levels and RDW among participants(β = 0.079, P

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0292569

DOI: 10.1371/journal.pone.0292569

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