Reinterpretation of the results of randomized clinical trials

Farrokh Habibzadeh

PLOS ONE, 2024, vol. 19, issue 6, 1-16

Abstract: Background: Randomized clinical trials (RCTs) shape our clinical practice. Several studies report a mediocre replicability rate of the studied RCTs. Many researchers believe that the relatively low replication rate of RCTs is attributed to the high p value significance threshold. To solve this problem, some researchers proposed using a lower threshold, which is inevitably associated with a decrease in the study power. Methods: The results of 22 500 RCTs retrieved from the Cochrane Database of Systematic Reviews (CDSR) were reinterpreted using 2 fixed p significance threshold (0.05 and 0.005), and a recently proposed flexible threshold that minimizes the weighted sum of errors in statistical inference. Results: With p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0305575

DOI: 10.1371/journal.pone.0305575

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