Active versus restrictive approach to isolated hypotension in preterm neonates: A Systematic Review, Meta-analysis and GRADE based Clinical Practice Guideline

Viraraghavan Vadakkencherry Ramaswamy, Gunjana Kumar, Abdul Kareem Pullattayil S, Abhishek S Aradhya, Pradeep Suryawanshi, Mohit Sahni, Supreet Khurana, Kiran More and on behalf of the National Neonatal Forum, India, Clinical Practice Guidelines Group on Neonatal Shock

PLOS ONE, 2025, vol. 20, issue 3, 1-15

Abstract: Objective: Isolated hypotension (IH) without any clinical or biochemical features of poor perfusion is a common occurrence in very preterm infants (VPTI). There exists no recommendations guiding its management.The objective of this review was to compare the effect of active vs. restrictive approach to treat IH in VPTI. Methodology: Medline, Embase and Web of Science were searched until 1st April 2024. RCTs and non-RCTs were included. Mortality, major brain injury (MBI) (intraventricular hemorrhage > grade 2 or cystic periventricular leukomalacia), mortality or neurodevelopmental impairment (NDI) at 18–24 months’ corrected age were the critical outcomes evaluated. Results: 44 studies were included: 9 were synthesized in a meta-analysis and 35 studies in the narrative review. Clinical benefit or harm could not be ruled out for the outcomes from the meta-analyses of RCTs. Meta-analysis of 3 non-RCTs suggested that active treatment of IH in VPTI of

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0309520

DOI: 10.1371/journal.pone.0309520

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