Does financial compensation matter for research participation in prevention trials in Tanzania? Perspectives of healthy volunteers

Raymond Athanas, Heavenlight A Paulo, Gasto Frumence, Masunga K Iseselo and Connie M Ulrich

PLOS ONE, 2025, vol. 20, issue 9, 1-12

Abstract: Background: Financial compensation is an important aspect of respect for people enrolled in clinical research, yet continues to raise ethical questions. Respondents’ characteristics, shaped by contextual and geographic factors, may influence perceptions of the ethical implications of financial compensation. This study explored the relationship between respondents’ characteristics and their ethical perspective on the role of financial compensation in prevention trials in Tanzania. Materials and methods: A cross-sectional survey of 537 participants from two prevention studies within Tanzania was conducted. Participants were eligible if they participated in either the HIV Pre-Exposure Prophylaxis Vaccine Trial (PrEPVacc) trial or a non-inferiority trial of low-dose compared to standard high-dose calcium supplementation in pregnancy in Tanzania. A questionnaire was used to collect participants’ sociodemographic characteristics and motivating reasons for research participation. Data analysis was performed using descriptive statistics for all variables. The chi-square test was used to assess associations between categorical demographic characteristics and binary outcomes scores. Modified Poisson regression models were employed to examine predictors of positive or negative perspectives for each outcome. The P value of

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0321353

DOI: 10.1371/journal.pone.0321353

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