Prevalence of Hepatitis C viral infection in Ghana: A systematic review and meta-analysis protocol

Peter Kwabena Fosu, Gill ten Hoor, Charles Ampong Adjei, Fidelis Atibila and Robert A C Ruiter

PLOS ONE, 2025, vol. 20, issue 4, 1-7

Abstract: BackgroundHepatitis C virus (HCV) infection remains a major public health concern for many countries. A recent survey report in Ghana revealed a national HCV prevalence rate of 4.6% in a population of 35 million but with notably higher regional variations ranging from 8.6 to 14.4%. Considering that Ghana is targeting micro-elimination of HCV as part of the STOP Hepatitis C project, it is prudent to estimate the current epidemiological burden of hepatitis C for evidence-based policymaking, public health research, and program direction. An initial search of the literature showed a previous review that spanned from 1995 to 2015. The gap of almost 10 years may not reflect the current burden of hepatitis C in Ghana, hence this review. A systematic literature search will be performed in the major electronic databases and search engines including PubMed, Embase, Web of Science, CINAHL, and African Journals Online (AJOL). There will be a search for articles reporting on the prevalence of hepatitis C in Ghana from 2016 to 2024 in these databases. The protocol is registered with PROSPERO (CRD42024592505).

Date: 2025
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DOI: 10.1371/journal.pone.0321483

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