Development of a novel risk score for diagnosing urinary tract infections: Integrating Sysmex UF-5000i urine fluorescence flow cytometry with urinalysis

Vo Anh Vinh Trang, Thien Tan Tri Tai Truyen, Minh Thuan Nguyen, Huu Phong Mai, Tri Cuong Phan, Son Hoang Phan, Han My Le Nguyen, Huong-Dung Thi Nguyen, Nguyen Hai Dang Le, Man Nhi Tu, Vo Thanh Vi Huynh, Hoang Tram Anh Nguyen, Dac Bao Han Ho, Ngoc Thuy Uyen Tran, Nguyen Ha Uyen Tran, Bich-Nhat Thi Le, Duc Tuan Doan, Huu Doan Pham, Truong Bao Phan, Phu Phat Pham, Tuan Vinh Nguyen and Phuc Cam Hoang Nguyen

PLOS ONE, 2025, vol. 20, issue 5, 1-14

Abstract: Background: Urinary tract infections (UTIs) are common globally, and are developing increased antibiotic resistance. Despite being the diagnostic “gold standard,” urine culture is limited by slow results and a high rate of false negative findings, leading to treatment delays, higher costs, and overuse of empirical antibiotics. Our study aims to develop a rapid and reliable model to predict clinical outcomes. Methods: From January 1st to October 31st, 2023, we enrolled patients with symptoms suggesting UTI from the Outpatient Department of our hospital. Inclusion criteria were patients aged ≥18, initially diagnosed with UTI, available urinalysis, flow cytometry, and urinary culture. Exclusion criteria included failed sample collection and cultures, and pregnant women. A case-control study was conducted, with UTI cases defined as ≥ 10^5 CFU/ µ L and controls as

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0323664

DOI: 10.1371/journal.pone.0323664

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