Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis

Solima Sabeel, Bongani Motaung, Kim A Nguyen, Mumin Ozturk, Sandra L Mukasa, Karen Wolmarans, Dirk J Blom, Karen Sliwa, Emmanuel Nepolo, Gunar Günther, Robert J Wilkinson, Claudia Schacht, Andre Pascal Kengne, Friedrich Thienemann and Reto Guler

PLOS ONE, 2025, vol. 20, issue 5, 1-20

Abstract: While numerous studies have extensively documented the pleiotropic effects of statins, including their capacity to reduce inflammation, there is a lack of research estimating the anti-inflammatory effectiveness of statins among individuals with chronic diseases. This meta-analysis evaluates the effect of statin therapy on inflammatory markers and the lipid profile in patients with chronic diseases by analysing evidence from randomized controlled trials (RCTs). We conducted a systematic review and searched articles published between 1st January 1999 and 31st December 2023 in databases including PubMed, Web of Science, Scopus, and Cochrane. The meta-analysis was performed using random effects models and inverse variance. Effect measures were mean differences (MD) and 95% confidence intervals (CI). Collectively, statins significantly reduced IL-6 (MD = -0.24 ng/dL [95% CI, -0.36 to -0.13], I2 = 98.3%, p

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0323749

DOI: 10.1371/journal.pone.0323749

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