Spatial analysis of mortality due to congenital syphilis in Brazil from 2008 to 2022

Yago Tavares Pinheiro, Richardson Augusto Rosendo da Silva, Ketyllem Tayanne da Silva Costa, Angelo Giuseppe Roncalli da Costa Oliveira, Janmilli Dantas da Costa, Cristiane da Silva Ramos Marinho, Jurandir Alves de Freitas Filho, Luennia Kerlly Alves Rocha, Victória Sampaio Moreira, Ruan Carlos de Queiroz Monteiro and José Rebberty Rodrigo Holanda

PLOS ONE, 2026, vol. 21, issue 2, 1-17

Abstract: The objective of this study is to analyze spatial distribution of mortality due to congenital syphilis in Brazil from 2008 to 2022. This is an ecological study that considered congenital syphilis deaths reported in all Brazilian municipalities, from 2008 to 2022, available in the Brazilian government’s information systems. We built a thematic map to describe the distribution of congenital syphilis mortality in the country and, subsequently, applied the Local Index Spatial Analysis to identify possible spatial clusters. Finally, we used the Ordinary Least Squares and Geographically Weighted Regression models to identify mortality predictors in the territory. The mortality rate from congenital syphilis was 0.64 deaths per 1,000 live births. The distribution of deaths occurred heterogeneously, with the highest rates in the states of Pará, Acre, Rondônia, Rio de Janeiro and part of Amazonas. We identified statistically significant spatial clusters across the country, with the formation of clusters with a high-high pattern in Pará, Rio de Janeiro, and Mato Grosso (p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0326407

DOI: 10.1371/journal.pone.0326407

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