The efficacy and safety of electrical acupoint stimulation (EAS) for knee osteoarthritis (KOA): A GRADE-assessed systematic review, meta-analysis and trial sequential analysis

Guangyi Yang, Rong Zhang, Botan Xu, Yi Yang, Yuxuan Wang, Wenjing Xu, Pengwei Li, Aotian Yu, Simin Ning, Qixuan Fu and Jianfeng Tu

PLOS ONE, 2025, vol. 20, issue 9, 1-27

Abstract: Electrical acupoint stimulation (EAS) is proposed as a potentially beneficial treatment for patients suffering from knee osteoarthritis (KOA). This systematic review and meta-analysis aims to assess the assess the effectiveness and safety of EAS for KOA. To identify eligible RCTs, a systematic search for eligible RCTs is conducted through 6 November 2024 in 12 electronic literature databases, utilizing relevant keywords. The analysis applies a random-effects model to compute RRs and 95% CIs for the dichotomous outcome, alongside the SMD and 95% CIs for continuous outcomes. This meta-analysis includes 63 RCTs with a total of 6475 participants. The pooled analysis reveals that EAS increases the overall response rate by 19.5% (RR: 1.195, 95% CI: 1.130 to 1.264, P

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0331568

DOI: 10.1371/journal.pone.0331568

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