Comparison of the triglyceride-glucose index and triglyceride-glucose-body mass index for predicting non-alcoholic fatty liver disease in elderly diabetic patients

Gaohui Zhu, Yihui Qu, Kanan Chen, Dingfa He, Jing Wang, Ziwei Tang, Xinyi Wang, Minqiao Zhang, Peilan Jiang, Ruijie Zhang and Kedan Cai

PLOS ONE, 2026, vol. 21, issue 2, 1-15

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is posing a challenge to global health systems. Developing an effective, simple, noninvasive method to identify NAFLD in elderly diabetic patients, track disease progression, and monitor treatment effects is importance. This study aims to assess the value of triglyceride-glucose index (TyG) and triglyceride-glucose-body mass index (TyG-BMI) in detecting NAFLD elderly patients with diabetes mellitus (DM). Methods: This study enrolled 6,882 individuals aged 60 years or older with DM who underwent liver ultrasonography in this cross-sectional study at Zhaobaoshan Residential District Community Health Service Center, from Jan. 1, 2015, to Oct. 19, 2023. And data was accessed for research purposes after Oct. 1,2024. Participants were randomly divided into a training group and a validation group in a 7:3 ratio. The diagnostic values of TyG and TyG-BMI were assessed using the area under the receiver-operating characteristic curve (AUROC) and Decision Curve Analysis (DCA). Two cut-off points were selected to rule out or rule in NAFLD, and we explored their specificity, sensitivity, negative predictive value, and positive predictive value. Results: There were 2,210 and 927 participants with NAFLD in the training and validation groups. In a fully adjusted model, TyG and TyG-BMI were correlated with an increased risk of NAFLD in the training group (TyG: OR=3.920, P

Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0341109 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 41109&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0341109

DOI: 10.1371/journal.pone.0341109

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().