JC polyomavirus (JCV, HPyV2) seropositivity prevalence in healthy subjects: Systematic review and meta-analysis

Lenka J Kimla and David Segal

PLOS ONE, 2026, vol. 21, issue 1, 1-18

Abstract: Background: JC polyomavirus (JCV, HPyV2) causes progressive multifocal leukoencephalopathy and has been linked to cancer development. JCV may naturally be highly prevalent in the human population and not just in diseased populations. Objective: The aim of this study was to the estimate the overall seroprevalence of JCV in the healthy human population by age of subjects, region or country of study, and assay methodology. Methods: A systematic review and meta-analysis with meta-regression using STATA 18. Results: Pooled JCV seroprevalence from 25 population-level studies (N = 18,331) was 61% (95% CI, 56% − 66%, z = 33.84, p

Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0341146 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 41146&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0341146

DOI: 10.1371/journal.pone.0341146

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().