Construction of a depression risk prediction model for hepatitis B patients based on machine learning strategy

Siyi Wang, Haoqi Liu, Chen Liang, Chui Kong, Jingchun Li, Min Wang, Kaiqiang Dong, Qianqi Wang, Dong Zhang and Rongjuan Guo

PLOS ONE, 2026, vol. 21, issue 2, 1-13

Abstract: Background: Hepatitis B (HBV) is a chronic viral infection that can lead to cirrhosis, liver failure, and liver cancer, and has a profound impact on the patient’s mental health. However, current depression screening mainly relies on self-filled scales and clinical experience, lacking objective and efficient prediction tools. This study aims to construct a risk prediction model for depression in hepatitis B patients based on machine learning, and explore the key features that affect the occurrence of depression, so as to optimize mental health management strategies. Methods: This study used the NHANES database to collect demographic, dietary, physical examination, laboratory test and questionnaire data. The data were standardized and SMOTE oversampling was used to solve the problem of class imbalance. Random Forest (RF) was used for feature screening to identify the top 20 most important predictive features, and five machine learning models (Gradient Boosting, Logistic Regression, AdaBoost, MLPClassifier, LDA) were used for prediction. The model performance was evaluated by AUC (area under the curve), accuracy, recall, precision and F1-score, and ROC curves, calibration curves, and decision curve analysis (DCA) were drawn to evaluate the clinical applicability of the model. Results: All five machine learning models performed well in the task of predicting the risk of depression in hepatitis B patients, among which MLPClassifier (multi-layer perceptron) performed best, with an AUC of 0.935, a recall of 0.980, and an F1-score of 0.917, which was better than other models. In addition, feature analysis results showed that liver function damage (serum total bilirubin, alkaline phosphatase), electrolyte imbalance (serum potassium ions), chronic inflammation (red blood cell distribution width, lymphocyte count), and socioeconomic factors (poverty-income ratio, race) were important factors affecting the risk of depression in hepatitis B patients. Conclusion: This study constructed an efficient and objective machine learning model that can be used to predict the risk of depression in patients with hepatitis B, providing a new tool for accurate screening and individualized management. The study revealed the potential mechanisms of physiological, biochemical and socioeconomic factors in the occurrence of depression in patients with hepatitis B, and provided a reference for future mental health intervention strategies.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0341236

DOI: 10.1371/journal.pone.0341236

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