Klotho levels and biological age acceleration: Insights from a diverse cohort of middle-aged and elderly individuals

Mengna Huang, Guoxin Huang, Chaoshen Wu, Lei Zhu, Bin Pei, Hongwei Wang, Da Qian and Puzhao Wu

PLOS ONE, 2026, vol. 21, issue 3, 1-17

Abstract: Objective: Aging is characterized by progressive physiological and psychological changes, leading to decreased cellular metabolism and increased vulnerability to age-related diseases. Methods.: In this study, we examined the relationship between circulating Klotho levels and biological age acceleration (BAA) in a representative cohort of middle-aged and older adults. Data were obtained from the National Health and Nutrition Examination Survey (NHANES, 2007–2010), including 5,654 participants aged 45–85 years. Serum Klotho concentrations were quantified using ELISA, while biological age was estimated with the BioAge R package. Result: Linear regression analyses demonstrated a robust inverse association between log-transformed Klotho levels and BAA across all statistical models, with reductions of −1.06 (95% CI: −1.77 to −0.36, p = 0.005), −1.44 (95% CI: −2.15 to −0.73, p

Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0343429 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 43429&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0343429

DOI: 10.1371/journal.pone.0343429

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().