Evaluating the effects of community-based programs on viral rebound and viral suppression among HIV-positive orphaned and vulnerable children receiving antiretroviral treatment: Findings from the ACHIEVE project in Tanzania

Amon Exavery, Daisy Kisyombe, Alison Koler, John Charles, Nemes Mallya, Erica Kuhlik, Asheri Barankena, Rose Fovo, Godfrey Martin Mubyazi, Tom Ventimiglia, Jennifer Mulik, Gloria Sangiwa and Levina Kikoyo

PLOS ONE, 2026, vol. 21, issue 5, 1-22

Abstract: Background: Achieving and sustaining viral load suppression (VLS) among children living with HIV remains challenging despite the availability of antiretroviral therapy (ART), primarily due to adherence difficulties. This study evaluated the effects of three interventions under the ACHIEVE project on viral load outcomes (viral rebound and viral suppression) among HIV-positive orphaned and vulnerable children aged 0–17 years (hereafter referred to as CLHIV) receiving ART in Tanzania. Methods: This is a longitudinal analysis of 26,257 CLHIV who are beneficiaries of the ACHIEVE project in Tanzania, each with at least two viral load (VL) test results between 2021 and 2023. VL outcomes were assessed using two analytic groups: Group 1 included 21,448 CLHIV with undetectable VL (

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0349141

DOI: 10.1371/journal.pone.0349141

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