Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada

Sylvia Aponte-Hao, Huong Luu, Karen J B Martins, Jason R Randall, Lynora Saxinger, Elissa Rennert-May, Jenine Leal, Tyler Williamson, Amanda Wilson, Michelle Blake, Tianyi Lu, Shehzad M Iqbal, James A Mansi, Andre B Araujo, David Martin and Scott W Klarenbach

PLOS ONE, 2026, vol. 21, issue 8, 1-21

Abstract: Background: With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination and additional (booster) doses. Methods: Adults (≥18 years) who received at least a primary vaccination schedule between December 2020 and March 2023 in Alberta, Canada were identified through population-level administrative data. Factors associated with severe COVID-19 outcomes (COVID-19 related hospitalization or death) were examined using univariable and multivariable Cox proportional hazard models. Results: Among those who received a primary vaccination schedule (n = 2,639,731), 0.2% (n = 5,475) had ≥ 1 severe COVID-19 outcome. Factors associated with a greater risk of a severe COVID-19 outcome included older age (≥65 versus

Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0354822 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 54822&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0354822

DOI: 10.1371/journal.pone.0354822

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().