Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study

Takayuki Yamaguchi, Keisuke Hosokawa, Takenori Mineta, Rie Hosokawa, Shiho Odawara, Rie Chiba, Kazue Asanuma, Setsuko Toyomaki, Mitsuho Sato, Fumiaki Takahashi, Shigeru Sakurai, Kazuhiro Takahashi and Tsuguo Nishijima

PLOS ONE, 2026, vol. 21, issue 9, 1-13

Abstract: Objectives: Obstructive sleep apnea (OSA) is characterized by systemic inflammation, intermittent hypoxemia, and immune dysregulation and has been associated with increased susceptibility to viral infections. In this study, we aimed to evaluate plasma concentrations of the antimicrobial peptide cathelicidin LL-37 (pLL-37) in individuals with OSA. Methods: The associations between pLL-37 levels, demographic characteristics, and polysomnographic (PSG) parameters were assessed in 58 individuals with OSA and 20 healthy controls. Participants were stratified into two groups stratified by apnea–hypopnea index (AHI): AHI

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0355855

DOI: 10.1371/journal.pone.0355855

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