Efficacy of nebulized salbutamol in transient tachypnea of the newborn: A systematic review and meta-analysis

Nanthida Phattraprayoon, Nut Koonrungsesomboon and Mingkwan Na Takuathung

PLOS ONE, 2026, vol. 21, issue 10, 1-24

Abstract: Transient tachypnea of the newborn (TTN) commonly affects near- and full-term infants and often requires respiratory support. The use of nebulized salbutamol to improve respiratory outcomes has been of interest, though its clinical efficacy remains controversial. This systematic review and meta-analysis aimed to evaluate whether nebulized salbutamol improves clinical outcomes in affected infants. We searched PubMed, Scopus, Embase, and the Cochrane Library for randomized controlled trials (RCTs) evaluating the efficacy of nebulized salbutamol in infants with TTN. We used a random-effects model to calculate mean differences (MDs) with 95% confidence intervals (CIs). Twenty-five studies were included in the systematic review, comprising seventeen RCTs for meta-analysis involving 1,317 infants. The analysis showed that salbutamol significantly decreased the duration of respiratory support (MD: −14.85 hours; 95% CI [−25.05, −4.65]; p = 0.004), duration of continuous positive airway pressure (MD: −18.19 hours; 95% CI [−30.03, −6.35]; p = 0.003), duration of oxygen requirement (MD: −24.57 hours; 95% CI [−35.03, −14.10]; p

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0359663

DOI: 10.1371/journal.pone.0359663

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