IN VIVO GASTROPROTECTIVE STUDY OF SELECTED ANTIOXIDANTS, VITAMINS AND MINERALS USING PYLORUS LIGATION INDUCED ULCERETED RATS

Darshan Shah ()
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Darshan Shah: HSBPVTS GOI COLLEGE OF PHARMACY,KASHTI

No 6709465, Proceedings of International Academic Conferences from International Institute of Social and Economic Sciences

Abstract: This investigation aimed to study the effect of selected antioxidants, vitamins and minerals on gastroprotection using pylorus ligation induced gastric mucosal damage in rats. The anti ulcerogenic effect of test substances was investigated in Albino Wistar rats, weighing between 200-250 g. were divided into 9 groups of 6 animals each (n=6). The groups were treated respectively as follows Group I normal control and Group II Positive control received normal saline, Group III was treated with standard drug Omeprazole, Group IV to IX received test substances respectively, two antioxidants (Vitamin E and Cystine) two vitamins (Vitamin B1 and Niacinamide) & two minerals (Iron and Zinc) for 5 days. Ulceration was induced by pylorus ligation. Various parameters like, the volume, pH of gastric juice, total acidity, ulcer index, percentage protection, biochemical parameters like mucin content, pepsin activity and antioxidant enzymes like Super oxide dismutase, catalase, reduced glutathione, myeloperoxidase, and malondialdehyde were estimated. Histopathology of stomach epithelium was observed. The ulcer index and total acidity were significantly reduced (p

Keywords: Antioxidants; Histopathology; Indomethacin; Myeloperoxidase; Minerals; Vitamins. (search for similar items in EconPapers)
JEL-codes: I10 (search for similar items in EconPapers)
Pages: 19 pages
Date: 2018-10
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Published in Proceedings of the Proceedings of the 41st International Academic Conference, Venice, Oct 2018, pages 197-215

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