The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression

Nur Ida Panca Nugrahini (), Agustin Krisna Wardani, Mohammad Saifur Rohman, Erryana Martati and Indah Nur Chomsy
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Nur Ida Panca Nugrahini: Universitas Brawijaya, Doctoral Program of Food Science and Biotechnology, Faculty of Agricultural Technology
Agustin Krisna Wardani: Universitas Brawijaya, Department of Food Science and Biotechnology, Faculty of Agricultural Technology
Mohammad Saifur Rohman: Universitas Brawijaya, Department of Cardiology and Vascular Medicine, Faculty of Medicine
Erryana Martati: Universitas Brawijaya, Department of Food Science and Biotechnology, Faculty of Agricultural Technology
Indah Nur Chomsy: University of Brawijaya, Doctoral Program of Medical Science, Faculty of Medicine

A chapter in Proceedings of the 2022 Brawijaya International Conference (BIC 2022), 2023, pp 466-476 from Springer

Abstract: Abstract The use of cost-effective herbs in the health sector is an exciting challenge in this era. Supported by environmentally friendly manufacturing processes, green tea and coffee can benefit health, one of which is metabolic syndrome (MetS). MetS therapy using green tea and green coffee, besides having health benefits, also has great potential in the economic sector because coffee is one of the largest sources of export commodities in Indonesia. Green tea and green coffee products as functional drinks are expected to be beneficial for health, one of which is obesity as a major risk factor in MetS. The purpose of this research is to determine the therapeutic effect of green tea and green coffee on molecular markers of obesity: gene expression of PPAR-γ and intracellular lipid accumulation from 3T3-L1 pre-adipocytes. Based on the results of this study, it was found that there was a significant difference between PPAR-γ and all groups (p = 0.00), and lipid accumulation between all groups (p = 0.00). There was a positive correlation between PPAR-γ and intracellular lipid accumulation with a p-value = 0.009 and an R = 0.610. Green tea and green coffee prevent obesity through inhibition of PPARγ gene expression which is characterized by decreased intracellular lipid accumulation in differentiated 3T3-L1 adipocytes.

Keywords: Green Coffee; Green Tea; PPAR-γ; Intracellular Lipid Accumulation (search for similar items in EconPapers)
Date: 2023
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DOI: 10.2991/978-94-6463-140-1_47

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