Potentially Inappropriate Medication Prescribing and Risk of Unplanned Hospitalization among the Elderly: A Self-Matched, Case-Crossover Study

Izumi Sato, Yosuke Yamamoto, Genta Kato and Koji Kawakami ()
Additional contact information
Izumi Sato: Kyoto University
Yosuke Yamamoto: Kyoto University
Genta Kato: Kyoto University Hospital
Koji Kawakami: Kyoto University

Drug Safety, 2018, vol. 41, issue 10, No 6, 959-968

Abstract: Abstract Introduction/Objectives An association between potentially inappropriate medication (PIM) use and adverse events has been established. However, PIM criteria for elderly patients and medical circumstance vary in different countries. We investigated the association between PIM use according to Japanese guidelines and unplanned hospitalization among elderly patients. Design A case-crossover study was conducted. Setting/Participants We used the Japanese Medical Data Vision database of 17.9 million people from 270 acute care hospitals across Japan. Records from 247,897 patients aged ≥ 65 years with unscheduled admissions between January 2009 and December 2015 were analyzed. Measurements We defined PIM use according to the Japanese Guidelines for Medical Treatment and Its Safety in the Elderly and used conditional logistic regression analysis to fit self-matched case-crossover models and compared each patient’s PIM use over five case periods (1, 2, 4, 8, and 12 weeks) prior to each unplanned hospitalization. Results We found the highest odds ratios (ORs) of unscheduled admission related to PIM use in the 1-week case period [OR 4.15; 95% confidence interval (CI) 4.05–4.25], followed by the 2-week (OR 3.01; 95% CI 2.95–3.07), 4-week (OR 3.91; 95% CI 3.83–4.00), 8-week (OR 2.00; 95% CI 1.96–2.05), and 12-week case periods (OR 1.48; 95% CI 1.44–1.51). Conclusions Elderly patients commonly used PIMs, especially antidiabetics and diuretics. PIM use was associated with a 1.5- to 4-fold increase in the ORs of unplanned hospitalization among them.

Date: 2018
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://link.springer.com/10.1007/s40264-018-0676-9 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:drugsa:v:41:y:2018:i:10:d:10.1007_s40264-018-0676-9

Ordering information: This journal article can be ordered from
http://www.springer.com/adis/journal/40264

DOI: 10.1007/s40264-018-0676-9

Access Statistics for this article

Drug Safety is currently edited by Nitin Joshi

More articles in Drug Safety from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().