Real-World Fetal Exposure to Acne Treatments in the United States: A Retrospective Analysis from 2006 to 2015

Yasser Albogami, Amir Sarayani, Juan M. Hincapie-Castillo and Almut G. Winterstein ()
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Yasser Albogami: University of Florida
Amir Sarayani: University of Florida
Juan M. Hincapie-Castillo: University of Florida
Almut G. Winterstein: University of Florida

Drug Safety, 2021, vol. 44, issue 4, No 7, 447-454

Abstract: Abstract Introduction Several studies have evaluated the effects of changes in isotretinoin risk mitigation programs, but little is known about actual fetal exposure rates in the context of other acne treatments. Objective Our objective was to quantify fetal exposure rates during the use of common acne treatments. Methods Employing the insurance claims data of > 100,000 acne treatment users between 2006 and 2015, we created three user cohorts: (1) isotretinoin (strong teratogen/mandatory risk mitigation program), (2) doxycycline/minocycline (mild teratogen, label warning), and (3) topical clindamycin/erythromycin (no fetal risk). Fetal exposure rates overall and stratified by age were compared after adjusting for potential confounders. Results Contraceptive use during acne treatment was

Date: 2021
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DOI: 10.1007/s40264-021-01053-3

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