A 13-Year National Monitoring Study to Assess Narcotic Prescriptions and Indications (2007–2019)

Joelle Perri-Plandé, Ghada Miremont-Salamé, Joëlle Micallef, Cameron Herman, Marie Baumevieille, Frédéric Abriat, Maryse Lapeyre-Mestre, Françoise Haramburu and Amélie Daveluy ()
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Joelle Perri-Plandé: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Ghada Miremont-Salamé: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Joëlle Micallef: Aix Marseille Univ, AP-HM, INSERM, Inst Neurosci Syst, Service de Pharmacologie Clinique et Pharmacovigilance
Cameron Herman: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Marie Baumevieille: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Frédéric Abriat: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Maryse Lapeyre-Mestre: Centre d’Addictovigilance, CHU, UMR-INSERM 1027
Françoise Haramburu: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU
Amélie Daveluy: Centre d’addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU

Drug Safety, 2022, vol. 45, issue 1, No 4, 37-44

Abstract: Abstract Introduction Analgesics are among the most widely used drugs worldwide. This study describes the population treated with narcotic analgesics, their therapeutic indications and how the data have evolved over a decade. Methods A cross-sectional, national, multicentre survey study was conducted that included surveys taken every year from 2007 to 2019 in a national sample of 1500 randomly selected dispensing pharmacies. Results The mean age of patients, mostly women (around 60%), remained stable over the study period (63.2 ± 17.1 years in 2007, 68.2 ± 17.2 years in 2019). The proportion of patients treated for more than 3 months increased from 2007 to 2019. Most prescriptions involved morphine, oxycodone and fentanyl (98.5% of all prescriptions in 2019). Morphine prescriptions dropped dramatically from 49.6% (2007) to 32.3% (2019) of the total narcotic analgesics. Fentanyl prescriptions varied from 40.1% in 2007 to 32.2% in 2019. Prescriptions of oxycodone, regardless of the indication, increased steadily from 2007, from 8.3 to 34% in 2019, becoming the most prescribed narcotic analgesic for the first time since the beginning of the survey. Conclusions This study demonstrates how narcotic opioids are prescribed, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone.

Date: 2022
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DOI: 10.1007/s40264-021-01124-5

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