A comparison of measurement properties between EORTC QLU-C10D and FACT-8D in patients with hematological malignances

Yiyin Cao (), Haofei Li (), Ling Jie Cheng (), Madeleine T. King (), Georg Kemmler (), David Cella (), Hongjuan Yu (), Weidong Huang () and Nan Luo ()
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Yiyin Cao: Harbin Medical University
Haofei Li: Harbin Medical University
Ling Jie Cheng: National University of Singapore
Madeleine T. King: University of Sydney
Georg Kemmler: Innsbruck Medical University
David Cella: Northwestern University
Hongjuan Yu: The First Affiliated Hospital of Harbin Medical University
Weidong Huang: Harbin Medical University
Nan Luo: National University of Singapore

Health Economics Review, 2024, vol. 14, issue 1, 1-10

Abstract: Abstract Objective To perform a comparison of the measurement properties of two cancer-specific Multi-Attribute Utility Instruments (MAUIs), EORTC QLU-C10D and FACT-8D, in Chinese patients with hematologic malignancies (HM). Methods We conducted a longitudinal study on patients with HM in China, using QLU-C10D and FACT-8D at baseline and follow-up (3–4 months from baseline). We assessed: (i) convergent validity using Spearman’s rank correlation test (r) with EQ-5D-5L; (ii) clinical-groups validity by differentiating cancer stages, overall health assessment (OHA), Eastern Cancer Oncology Group (ECOG) performance status, and mental health status. We also examined clinical validity with effect size (ES) and relative efficiency (RE); (iii) responsiveness to changes in patient self-perception using receiver operating characteristics (ROC) curves and area under the curves (AUC); and (iv) agreement using intraclass correlation coefficients (ICC) and visualized with Bland-Altman plot. Results Among the 308 patients with HM at baseline, 131 completed the follow-up survey. Agreement between the two measures was high (ICC = 0.76). Both measures were highly correlated with EQ-5D-5 L and significantly differentiated (p

Keywords: QLU-C10D; FACT-8D; Measurement properties; Cancer; Hematological malignance (search for similar items in EconPapers)
Date: 2024
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DOI: 10.1186/s13561-024-00560-0

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