Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence

Simone Ohlwein (), Ron Kappeler, Meltem Kutlar Joss, Nino Künzli and Barbara Hoffmann
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Simone Ohlwein: Heinrich-Heine-University Düsseldorf
Ron Kappeler: Switzerland and University of Basel
Meltem Kutlar Joss: Switzerland and University of Basel
Nino Künzli: Switzerland and University of Basel
Barbara Hoffmann: Heinrich-Heine-University Düsseldorf

International Journal of Public Health, 2019, vol. 64, issue 4, No 9, 547-559

Abstract: Abstract Objectives Due to their small size, ultrafine particles (UFP) are believed to exert higher toxicity than larger particles. As numerous studies on health effects of UFP have been published since the last systematic review in 2013, we aim to systematically review the new literature. Methods We searched MEDLINE and the specialized LUDOK database for studies published between 01.01.2011 and 11.05.2017 investigating health effects of ambient air pollution-related UFP. We included epidemiologic studies containing UFP measures and quantifiable measures of associations. Relevant data were extracted on the basis of previously developed evaluation criteria. Results We identified 85 original studies, conducting short-term (n = 75) and long-term (n = 10) investigations. Panel (n = 32), scripted exposure with predefined settings (n = 16) or time series studies (n = 11) were most frequent. Thirty-four studies adjusted for at least one other pollutant. Most consistent associations were identified for short-term effects on pulmonary/systemic inflammation, heart rate variability and blood pressure. Conclusions The evidence suggests adverse short-term associations with inflammatory and cardiovascular changes, which may be at least partly independent of other pollutants. For the other studied health outcomes, the evidence on independent health effects of UFP remains inconclusive or insufficient.

Keywords: Ultrafine particles; Air pollution; Epidemiology; Health effects; Particulate matter (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (14)

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DOI: 10.1007/s00038-019-01202-7

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