Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis

Biruk Beletew Abate (), Ayelign Mengesha Kasie (), Melese Abate Reta () and Mesfin Wudu Kassaw ()
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Biruk Beletew Abate: Woldia University
Ayelign Mengesha Kasie: Woldia University
Melese Abate Reta: Woldia University
Mesfin Wudu Kassaw: Woldia University

International Journal of Public Health, 2020, vol. 65, issue 9, No 14, 1623-1633

Abstract: Abstract Objectives This systematic review and meta-analysis aimed to reveal the magnitude of neonatal sepsis and its associated factors in East Africa. Methods Using PRISMA guideline, we reviewed and meta-analyzed studies from Google Scholar, Cochrane library, and PubMed; last search date: October 15, 2019. Heterogeneity across the studies was estimated. The subgroup analysis was done. Publication bias was also assessed. Results A total of 26 studies with 11,239 participants are included. The pooled prevalence of neonatal sepsis in East Africa was 29.765% (95% CI 23.36–35.94). Home delivery (AOR = 2.67; 95% CI 1.15–4.00), maternal history of urinary tract infection (UTI) (AOR = 2.083; 95% CI 0.24–3.93), gestational age/(preterm) (AOR = 1.56; 95% CI 1.04–2.08), prolonged labor (AOR = 3.23; 95% CI 0.04–6.51) and PROM (AOR = 1.95; 95% CI 0.53–3.37) were identified associated factors of neonatal sepsis. Conclusions The prevalence of neonatal sepsis in East Africa remains high. The relevant stockholders should give attention for neonates delivered from women with intranatal fever to prevent neonatal sepsis. Pregnant women should be screened for UTI. Appropriate interventions should be put in place to manage PROM to decrease the chance of ascending microorganisms.

Keywords: Neonatal sepsis; Prevalence; Risk factors; Systematic review; Meta-analysis; East Africa (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1007/s00038-020-01489-x

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