Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics

Lubomír Skladaný (), Marian Oltman (), Soňa Fraňková (), Sylvia Dražilová (), Petr Husa (), Jan Šperl (), Václav Hejda (), Petr Urbánek (), Svetlana Adamcová-Selčanová (), Martin Janičko (), Pavol Kristian (), Viera Kupčová (), Marek Rác (), Ivan Schréter (), Ladislav Virág (), Adriana Liptáková (), Miriam Ondrášová () and Peter Jarčuška ()
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Lubomír Skladaný: FD Roosevelt University Hospital of Slovak Medical University, HEGITO (Division Hepatology, Gastroenterology and Liver Transplantation)
Marian Oltman: Center for Gastroenterology and Hepatology Thalion
Soňa Fraňková: Institute for Clinical and Experimental Medicine
Sylvia Dražilová: Hospital Poprad
Petr Husa: Masaryk University
Jan Šperl: Institute for Clinical and Experimental Medicine
Václav Hejda: Charles University Medical School and Teaching Hospital
Petr Urbánek: Charles University and Central Military Hospital
Svetlana Adamcová-Selčanová: FD Roosevelt University Hospital of Slovak Medical University, HEGITO (Division Hepatology, Gastroenterology and Liver Transplantation)
Martin Janičko: P.J. Safarik University and L. Pasteur University Hospital
Pavol Kristian: P.J. Safarik University and L. Pasteur University Hospital
Viera Kupčová: Derer’s Hospital
Marek Rác: Teaching Hospital
Ivan Schréter: P.J. Safarik University and L. Pasteur University Hospital
Ladislav Virág: P.J. Safarik University and L. Pasteur University Hospital
Adriana Liptáková: Commenius University
Miriam Ondrášová: Abbvie Slovakia and PhD. Studies at Saint Elisabeth University of Health and Social Sciences
Peter Jarčuška: P.J. Safarik University and L. Pasteur University Hospital

International Journal of Public Health, 2020, vol. 65, issue 9, No 23, 1723-1735

Abstract: Abstract Objectives The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. Methods MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. Results Among 220 patients enrolled, 51.4% were treatment-naïve. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naïve (63.4%). Most participants (67.7%) presented viral RNA load of ≥ 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. Conclusions The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.

Keywords: Chronic HCV infection; HCV genotype; HCV liver disease; Czech Republic; Slovakia; Anti-HCV therapy (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1007/s00038-020-01496-y

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