Unmet Parenthood Goals, Health-Related Quality of Life and Apparent Irrationality: Understanding the Value of Treatments for Infertility

Chris Skedgel (), Patricia Cubi-Molla, David Mott, Sofia Gameiro, Jacky Boivin, Hareth Al-Janabi, John Brazier, Marie Markert, Fredrik L. Andersson and Mireia Jofre-Bonet
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Chris Skedgel: Goldings House
Patricia Cubi-Molla: Goldings House
David Mott: Goldings House
Sofia Gameiro: University of Cardiff
Jacky Boivin: University of Cardiff
Hareth Al-Janabi: University of Birmingham
John Brazier: University of Sheffield
Marie Markert: Ferring Pharmaceuticals A/S
Fredrik L. Andersson: Ferring Pharmaceuticals A/S
Mireia Jofre-Bonet: Goldings House

PharmacoEconomics - Open, 2023, vol. 7, issue 3, No 1, 337-344

Abstract: Abstract An increasing number of prospective parents are experiencing infertility along with associated negative impacts on mental health and life satisfaction that can extend across a network of individuals and family members. Assistive reproductive technologies (ART) can help prospective parents achieve their parenthood goals but, like any health technology, they must demonstrate acceptable 'value for money' to qualify for public funding. We argue that current approaches to understanding the value of ART, including quality-adjusted life-year (QALY) gains based on changes in health-related quality of life (HRQOL) and, more often, cost per live birth, are too narrow to capture the full impact of unmet parenthood goals and ART. We see a fundamental disconnect between measures of HRQOL and broader measures of wellbeing associated with met and unmet parenthood goals. We also suggest that simple concepts such as 'patient' and 'carer' are of limited applicability in the context of ART, where 'spillovers' extend across a wide network of individuals, and the person receiving treatment is often not the infertile individual. Consideration of individual and societal wellbeing beyond HRQOL is necessary to understand the full range of negative impacts associated with unmet parenthood goals and the corresponding positive impacts of successful ART. We suggest moving towards a wellbeing perspective on value to achieve a fuller understanding of value and promote cross-sector allocative efficiency.

Date: 2023
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DOI: 10.1007/s41669-023-00402-5

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