Robust Modality Selection in Radiotherapy

Sevnaz Nourollahi, Archis Ghate and Minsun Kim ()
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Sevnaz Nourollahi: University of Washington
Archis Ghate: University of Washington
Minsun Kim: University of Washington

A chapter in Advances in Service Science, 2019, pp 11-20 from Springer

Abstract: Abstract External beam radiotherapy attempts to maximize tumor-damage while limiting toxicity on healthy tissue. Although several modalities with distinctive biological and physical properties are available, none is dominant. A mathematical formulation for optimal modality selection with uncertainty in these properties is presented. Uncertainty is incorporated via a robust approach. The problem decomposes into finitely many subproblems with analytically solvable Karush-Kuhn-Tucker conditions. Numerical experiments demonstrate how uncertainty affects optimal solutions even when clinical intuition is not readily available.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:spr:prbchp:978-3-030-04726-9_2

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DOI: 10.1007/978-3-030-04726-9_2

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