Improvement of the Manufacturing Process of Active Pharmaceutical Ingredients

A. C. P. Soares and R. D. S. Campilho
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A. C. P. Soares: ISEP—School of Engineering, Polytechnic of Porto, R. Dr. António Bernardino de Almeida
R. D. S. Campilho: ISEP—School of Engineering, Polytechnic of Porto, R. Dr. António Bernardino de Almeida

A chapter in Driving Quality Management and Sustainability in VUCA Environments, 2024, pp 15-28 from Springer

Abstract: Abstract Currently, the pharmaceutical industry needs to optimize industrial drug processing procedures. The constant improvement of industrial equipment is an unavoidable strategy to improve the quality of the process, as well as its efficiency and productivity. This work aims to analyze and implement improvements in equipment integrated into production processes in pharmaceutical laboratories to produce active pharmaceutical ingredients (APIs). In the project, studies were carried out using the finite element method (FEM) and traditional structural design, to test the feasibility of the selected solutions. Then, the cost analysis was carried out, and the benefits and results of the new equipment were presented. It was possible to conclude that the proposed equipment demonstrates advantages at an ergonomic, hygienic, and practical level compared to the original ones, which translates into an increase of the company’s competitiveness in the pharmaceutical market.

Keywords: Pharmaceutical industry; Active pharmaceutical ingredients; Spray drying; Standardization; Process improvement; Finite element method (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:spr:prbchp:978-3-031-52723-4_2

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DOI: 10.1007/978-3-031-52723-4_2

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