Mechanisms and Biological Markers of Carcinogenesis

Regina M. Santella

Chapter 1 in Cancer Precursors, 2002, pp 7-19 from Springer

Abstract: Conclusion Advances in basic research on the cellular and molecular mechanisms of carcinogenesis have contributed to our understanding of this complex multistage disease. This research has also led to the development of methods to monitor humans for early stages of disease. Studies on DNA and protein adducts have demonstrated associations of higher levels of adducts with disease status. However, these results have not been applicable to the individual; higher DNA adducts are not proof of higher risk. More-recent studies, identifying tumor cells or mutated DNA in biospecimens, hold promise for the early identification of subjects with preclinical discease. Considerably more research will be necessary however, before these assays can be used for routine medical care.

Keywords: Natl Cancer Inst; Sister Chromatid Exchange; Chemical Carcinogen; Protein Adduct; Mosomal Aberration (search for similar items in EconPapers)
Date: 2002
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DOI: 10.1007/0-387-21605-7_2

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