Statistical Procedures for Low Dose Extrapolation of Quantal Response Toxicity Data

John Kovar and Daniel Krewski
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John Kovar: Health and Welfare Canada
Daniel Krewski: Health and Welfare Canada

A chapter in Computer Science and Statistics: Proceedings of the 13th Symposium on the Interface, 1981, pp 367-370 from Springer

Abstract: Abstract Maximum likelihood procedures for fitting the probit, logit, Weibull and gamma multi-hit dose response models with independent, additive or mixed independent/additive background to quantal assay toxicity data are reviewed. In addition to parameter estimation, the use of the above models for low dose extrapolation is indicated with both point estimates and lower confidence limits on the “safe” dose discussed. A computer program implementing these procedures is described and two sets of toxicity data are analyzed to illustrate its use.

Keywords: virtually safe dose; risk estimation; dose response models; maximum likelihood estimation (search for similar items in EconPapers)
Date: 1981
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-1-4613-9464-8_61

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DOI: 10.1007/978-1-4613-9464-8_61

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