Comparing Two Treatments in a Large Phase III Clinical Trial

Michaela Jahn
Additional contact information
Michaela Jahn: F. Hoffmann-La Roche AG

Chapter 12 in Applied Statistics in the Pharmaceutical Industry, 2001, pp 299-320 from Springer

Abstract: Abstract This chapter outlines some of the analyses performed for a Phase III oncology trial. The trial was conducted by F. Hoffmann-La Roche and took place between 1996 and 1998. More than 600 cancer patients receiving either a new experimental therapy or a standard treatment were included in the trial. Besides a description of the data, the statistical analysis methods used for some of the analyses are detailed (with an emphasis on survival analysis). The applications of the methods using S-Plus are outlined. The focus is on the analyses as specified in the trial protocol. Due to space limitation, not all analyses performed for the trial are mentioned and not all aspects of the trial are presented.

Keywords: Experimental Treatment; Metastatic Site; Partial Responder; Complete Responder; Tumor Assessment (search for similar items in EconPapers)
Date: 2001
References: Add references at CitEc
Citations:

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-1-4757-3466-9_12

Ordering information: This item can be ordered from
http://www.springer.com/9781475734669

DOI: 10.1007/978-1-4757-3466-9_12

Access Statistics for this chapter

More chapters in Springer Books from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().