Reporting Biases

S. Swaroop Vedula (), Asbjørn Hróbjartsson () and Matthew J. Page ()
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S. Swaroop Vedula: The Johns Hopkins University, Malone Center for Engineering in Healthcare, Whiting School of Engineering
Asbjørn Hróbjartsson: University of Southern Denmark, Cochrane Denmark and Centre for Evidence-Based Medicine Odense
Matthew J. Page: Monash University, School of Public Health and Preventive Medicine

Chapter 103 in Principles and Practice of Clinical Trials, 2022, pp 2045-2071 from Springer

Abstract: Abstract Clinical trials are experiments in human beings. Findings from these experiments, either by themselves or within research syntheses, are often meant to evidence-based clinical decision-making. These decisions can be misled when clinical trials are reported in a biased manner. For clinical trials to inform healthcare decisions without bias, their reporting should be complete, timely, transparent, and accessible. Reporting of clinical trials is biased when it is influenced by the nature and direction of its results. Reporting biases in clinical trials may manifest in different ways, including results not being reported at all, reported in part, with delay, or in sources of scientific literature that are harder to access. Biased reporting of clinical trials in turn can introduce bias into research syntheses, with the eventual consequence being misinformed healthcare decisions. Clinical trial registration, access to protocols and statistical analysis plans, and guidelines for transparent and complete reporting are critical to prevent reporting biases.

Keywords: Reporting biases; Publication bias; Outcome reporting bias; Time lag bias; Location bias; Language bias; Duplicate reporting; Spin; Citation bias (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/978-3-319-52636-2_183

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