Controlling for Multiplicity, Eligibility, and Exclusions

Amber Salter () and J. Philip Miller ()
Additional contact information
Amber Salter: Washington University School of Medicine in St. Louis, Division of Biostatistics
J. Philip Miller: Washington University School of Medicine in St. Louis, Division of Biostatistics

Chapter 39 in Principles and Practice of Clinical Trials, 2022, pp 729-737 from Springer

Abstract: Abstract Multiple comparison procedures play an important role in controlling the accuracy of clinical trial results while trial eligibility and exclusions have the potential to introduce bias and reduce external validity. This chapter introduces the issues and sources of multiplicity and provides a description of the many different procedures that can be used to address multiplicity primarily used in the confirmatory clinical trial setting. Additionally, trial inclusion/exclusion criteria and enrichment strategies are reviewed.

Keywords: Multiple comparison procedures; Inclusion/exclusion criteria; Enrichment strategies (search for similar items in EconPapers)
Date: 2022
References: Add references at CitEc
Citations:

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-319-52636-2_210

Ordering information: This item can be ordered from
http://www.springer.com/9783319526362

DOI: 10.1007/978-3-319-52636-2_210

Access Statistics for this chapter

More chapters in Springer Books from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().