Pharmacoepidemiology

Edeltraut Garbe and Samy Suissa
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Edeltraut Garbe: Charité-University Medicine Berlin, Institute for Clinical Pharmacology
Samy Suissa: McGill University, Departments of Epidemiology and Biostatistics

Chapter III.9 in Handbook of Epidemiology, 2005, pp 1225-1266 from Springer

Abstract: Abstract In the last two decades we have witnessed a tremendous progress in the medical sciences that has led to the development of a great number of new powerful pharmaceuticals. These new medicines enable us to provide much better medical care, but occasionally they will cause harm and give rise to serious adverse reactions that were unexpected from preclinical studies or premarketing clinical trials. Against this background, pharmacoepidemiology has developed as a scientific discipline at the interface between clinical pharmacology and clinical epidemiology (cf. Chap. III.8 of this handbook). Pharmacoepidemiology can be defined as the application of epidemiologic knowledge, methods, and reasoning to the study of the effects and uses of drugs in human populations (Porta-Serra and Hartzema 1997). The application of epidemiological methods – i.e. the use of nonexperimental observational techniques –, the epidemiological perspective with an emphasis on investigations in large unselected populations and long-term studies, the public health approach and the philosophy of epidemiology are all extended to the scope of clinical pharmacology, i.e. the study of the effects of pharmaceuticals in humans.

Keywords: Chronic Obstructive Pulmonary Disease; Propensity Score; Drug Utilization; General Practice Research Database; Cohort Entry (search for similar items in EconPapers)
Date: 2005
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DOI: 10.1007/978-3-540-26577-1_31

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