Coupled Problems in Computational Modeling of the Respiratory System

Lena Wiechert (), Timon Rabczuk (), Michael Gee (), Robert Metzke () and Wolfgang A. Wall ()
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Lena Wiechert: Technical University of Munich, Chair of Computational Mechanics
Timon Rabczuk: Technical University of Munich, Chair of Computational Mechanics
Michael Gee: Technical University of Munich, Chair of Computational Mechanics
Robert Metzke: Technical University of Munich, Chair of Computational Mechanics
Wolfgang A. Wall: Technical University of Munich, Chair of Computational Mechanics

A chapter in High Performance Computing on Vector Systems 2007, 2008, pp 145-166 from Springer

Abstract: Abstract Biomechanical simulations are an important field of application for high performance computing due to the complexity and largeness of involved problems. This paper is concerned with coupled problems in the human respiratory system with emphasis on mechanical ventilation. In this context we focus on the modeling aspects of pulmonary alveoli and the lower airways. Our alveolar model is based on artificially generated random geometries and takes into account realistic tissue behavior as well as interfacial phenomena. On the part of the structural solver a smoothed aggregation algebraic multigrid method is used. For the first four generations of the bronchial tree, a geometry based on human computer tomography scans obtained from in-vivo experiments is employed. With the help of fluid-structure interaction simulations, flow patterns and airway wall stresses for normal breathing and mechanical ventilation of the healthy and diseased lung are investigated.

Keywords: Mechanical Ventilation; Null Space; Multigrid Method; Airway Wall; Couple Problem (search for similar items in EconPapers)
Date: 2008
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DOI: 10.1007/978-3-540-74384-2_12

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