Antibody Titres and Two Types of Bias

Jozef Nauta ()
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Jozef Nauta: Global Statistics, Solvay Pharmaceuticals

Chapter Chapter 4 in Statistics in Clinical Vaccine Trials, 2011, pp 47-55 from Springer

Abstract: Abstract Statisticians have pointed out that when antibody titres are determined using the standard definition (see Sect. 2.1.2), the reciprocal of the highest dilution at which the assay read-out did occur, the true titre value is underestimated [23]. This is easy to see. By definition, the true antibody titre τ lies between the standard titre t s and the reciprocal of the next dilution, r n : $${t}_{s} \leq \tau

Date: 2011
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DOI: 10.1007/978-3-642-14691-6_4

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