The Relation Between the Gene Network and the Physical Structure of Chromosomes

Dieter W. Heermann (), Manfred Bohn and Philipp M. Diesinger
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Dieter W. Heermann: University of Heidelberg, Institute for Theoretical Physics
Manfred Bohn: University of Heidelberg, Institute for Theoretical Physics
Philipp M. Diesinger: University of Heidelberg, Institute for Theoretical Physics

A chapter in Modeling, Simulation and Optimization of Complex Processes, 2012, pp 153-167 from Springer

Abstract: Abstract Human cells contain 46 chromosomes with a total length of about 5 cm beads-ona- string type of nucleosomal fibre, called chromatin. Packaging this into a nucleus of typically 5–20 μm diameter requires extensive compatification. This packaging cannot be random, as considerable evidence has been gathered that chromatin folding is closely related to local genome function. However, the different levels of compactification are ill understood and not easily accessible by experiments.

Keywords: Interphase Nucleus; Polymer Model; Nucleosome Occupancy; Linker Histone; Depletion Effect (search for similar items in EconPapers)
Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-642-25707-0_13

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DOI: 10.1007/978-3-642-25707-0_13

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