Investigation of Precursor-Product Relationships in Radiotracer Studies

Michael E. Jones and Karen Taransky
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Michael E. Jones: Flinders University of South Australia, School of Medicine
Karen Taransky: Flinders University of South Australia, School of Medicine

A chapter in Biomathematics and Related Computational Problems, 1988, pp 473-481 from Springer

Abstract: Abstract Radiotracer studies are often carried out in situations where pools bearing a precursor-product relationship have yet to be identified. Where the pools of interest are not directly accessible for input, or where there is recirculation of tracer, the problems of defining precursor-product reltionships and of determining the metabolic flux from precursor to product are complex. This is essentially an inverse problem in compartmental analysis, involving data which is not error-free. We adopt the approach of identifying those pools between which a steady-state compartmental precursor-product relationship can be confidently rejected. The approach can be extended to models involving non-compartmental behaviour.

Keywords: Metabolic Flux; Turnover Time; Alveolar Type; Lamellar Body; Area Plot (search for similar items in EconPapers)
Date: 1988
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-94-009-2975-3_42

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DOI: 10.1007/978-94-009-2975-3_42

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