Regression analysis of misclassified current status data

Shuwei Li, Tao Hu and Jianguo Sun

Journal of Nonparametric Statistics, 2020, vol. 32, issue 1, 1-19

Abstract: Misclassified current status data occur when each subject under study is observed only once and the failure status at the observation time is determined by a diagnostic test with imperfect sensitivity and specificity. In this article, we provide a methodology for the analysis of such data under a wide class of flexible semiparametric transformation models. For inference, a nonparametric maximum likelihood estimation procedure is proposed along with the development of an EM algorithm. Furthermore, we show that the resulting estimators of regression parameters are consistent, asymptotically normal and semiparametrically efficient. A simulation study and a real data application demonstrate that the proposed approach performs well in practice and has substantial superiority over the naive method that ignores the misclassification.

Date: 2020
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DOI: 10.1080/10485252.2019.1687892

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