Kernel-Based Response-Adaptive Design for Continuous Responses

Uttam Bandyopadhyay, Atanu Biswas and Rahul Bhattacharya

Communications in Statistics - Theory and Methods, 2009, vol. 38, issue 16-17, 2691-2705

Abstract: Response-adaptive designs are becoming popular in phase III clinical trials. We propose a response-adaptive design for a general class of continuous responses. The design is based on two kernels and does not require the existence of any moment of the response variables, and thus applicable for any type of continuous responses, even if the distribution is non-standard or the existence of moments of the response distribution is not guaranteed. Some possible properties of the design are discussed and are compared with some existing procedures. The methodology is illustrated by using some real life data.

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:taf:lstaxx:v:38:y:2009:i:16-17:p:2691-2705

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DOI: 10.1080/03610910902936216

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