Sequential Testing to Guarantee the Necessary Sample Size in Clinical Trials

Andrew L. Rukhin

Communications in Statistics - Theory and Methods, 2009, vol. 38, issue 16-17, 3114-3122

Abstract: This article addresses the sequential sampling issues related to attainment of a given number of subjects in a Poisson arrival process. The problem of guaranteeing the necessary sample size is formulated as that of open-ended hypothesis testing. To implement the procedure a one-sided stopping boundary must be specified. The formulas for the probabilities of general stopping time distribution are derived. For the linear boundary they are in the class of Lagrangian Poisson distributions. A locally optimal test is obtained.

Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:taf:lstaxx:v:38:y:2009:i:16-17:p:3114-3122

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DOI: 10.1080/03610920902947584

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