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Long term simulation analysis of deceased donor initiated chains in kidney exchange programs

Utkarsh Verma, Nayaran Rangaraj, Viswanath Billa and Deepa Usulumarty

Health Systems, 2024, vol. 13, issue 2, 121-132

Abstract: Kidney exchange programs (KEPs) aim to find compatible kidneys for recipients with incompatible donors. Patients without a living donor depend upon deceased donor (DD) donations to get a kidney transplant. In India, a ©DD donates kidneys directly to a©DD wait-list. The idea of initiating an exchange chain starting from a ©DD kidney is proposed in a few articles (and executed in Italy in 2018), but no mathematical formulation has been given for this merger. We have introduced an integer programming formulation that creates ©DD-initiated chains, considering both paired exchange registry and ©DD allocations simultaneously and addressing the overlap issue between the exchange registry and ©DD wait-list as recipients can register for both registries independently. A long-term simulation study is done to ©analyse the gain of these DD-initiated chains over time. It suggests that even with small numbers of ©DDs, these chains can significantly increase potential transplants.

Date: 2024
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DOI: 10.1080/20476965.2023.2197023

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