Efflux Pump Inhibitors as a Broad-Spectrum Strategy to Combat Multidrug Resistance Acenitobacter Baumanii

Ayat Alaaeldin Abdulazeez and Zainab Salim Jaafar
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Ayat Alaaeldin Abdulazeez: Department of Basic Sciences, College of Dentistry, University of Kerbala, Kerbala, Iraq
Zainab Salim Jaafar: Department of Bioinformatics, College of Biomedical Informatics, University of Information Technology and Communications, Baghdad, Iraq.

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2024, vol. 10, 11-23

Abstract: The World Health Organization (WHO) identifies A. baumannii as one of the most resistant pathogens. Over the past few years, there has been a significant rise in its resistance to a wide array of antibiotics. Multidrug resistance is attributed to several mechanisms, with efflux pumps being the most notable. Recently, the development of new treatment strategies to tackle A. baumannii infections has shown great promise. This review focuses on the various families of efflux pumps in A. baumannii and explores innovative therapeutic options that have emerged over the past four years. Specifically, we emphasize synthetic and natural efflux pump inhibitors (EPIs), nanoparticles, bacteriophage therapy, and antimicrobial peptides (AMPs) as part of these novel strategies.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:ojs:11738

DOI: 10.47577/biochemmed.v10i.11738

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